Restriction-modification systems as genomic parasites in competition for specific sequences.
نویسندگان
چکیده
منابع مشابه
Restriction modification systems as engines of diversity
Restriction modification (RM) systems provide protection against a broad spectrum of phages. However, the likelihood of a phage permanently bypassing this can be as high as 0.1 per infection (Korona et al., 1993) which makes for a relatively weak defense. Here we argue that, apart from providing such transient defenses, RM systems can facilitate long-term coexistence of many bacterial strains. ...
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A restriction (R) endonuclease recognizes a specific DNA sequence and introduces a double-strand break (Fig. 1A). A cognate modification (M) enzyme methylates the same sequence and thereby protects it from cleavage. Together, these two enzymes form a restriction-modification system. The genes encoding the restriction endonuclease and the cognate modification enzyme are often tightly linked and ...
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We identify a new subgroup of Type I Restriction-Modification enzymes that modify cytosine in one DNA strand and adenine in the opposite strand for host protection. Recognition specificity has been determined for ten systems using SMRT sequencing and each recognizes a novel DNA sequence motif. Previously characterized Type I systems use two identical copies of a single methyltransferase (MTase)...
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Pressure Reducing Valves (PRV) are being used for decreasing the existing extra pressure in the water distribution network. however, they dissipate a considerable amount of energy. Therefore, the idea of application of Soft Pressure Reducing Systems (SPRS) is proposed, where a PRV is replaced by a hydropower station. The heart of An SPRS is the turbo-generator. One of the advantages of this typ...
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The sequence specificities of three Bacillus subtilis restriction/modification systems were established: (i) BsuM (CTCGAG), an isoschizomer to XhoI; (ii) BsuE (CGCG), an isoschizomer to FnuDII; and (iii) BsuF (CCGG), an isoschizomer to MspI, HpaII. The BsuM modification enzyme methylates the 3' cytosine of the recognition sequence. The BsuF modification enzyme methylates the 5' cytosine of the ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1995
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.92.24.11095